600 whp and 100k? You're most likely looking at some big Garretts for that out of a 3 liter, and get a side order of good luck while you're at it. We have several people making good power at 50k+ on upgraded turbos but it really depends on driving style, maintenance, attention to detail etc. You guys have to have some honesty with that. 10k racing or with an aggressive driver is far harder on them than 30k commuting with an occasional rip up to highway speeds, so mileage in and of itself isn't going to be everything. I consider myself hard on turbos, but it's nothing compared to Tony "lets make 950 ft lbs and see what happens Vargas".
In general, shaft speed is very highly correlated with life expectancy. When you run parts hard you absolutely will get decreased lifespan. If you want OEM reliability and huge power output... you're going to need a little more displacement to play with. Or you're going to need some big lazy compressors that are loafing along at 25 psi, and have the lag and spool to go with that.
Efficiencies in the flow path can help quite a bit, as can fuel that's worth actually burning (i.e. not ACN91). A good tuner is worth their weight in gold. As it is though, boost is cheap, so the average response is to turn it up, don't think about back pressure, compressor maps, efficiency, heat, oil change intervals, etc. This is why I try to talk to customers about how they really want to drive the car, what they use for fuel, their mods and their expectations both with power and reliability.
Chris