The OTS maps are not really meant to run full E85. They interpolate correctly up to E50/60, and ALLOW use of up to E85 as a convenience by reducing boost target, etc, while keeping fuel maxed for higher blends. If you really want to run E0 - E85 / 100, you should get a custom tune.
Perhaps I am misunderstanding this comment, but isn't the entire point of flex fuel to ALLOW for running ANY ethanol blend? Sure, you might not get max performance with e85 if your fuel system can't deliver it, hence the interpolation breakpoint. I'm on a custom tune and while I could run E85, my fuel system is capped power wise around E40, so above that, boost target, et al, would be reduced.
I don't see why it being an OTS map or a custom tune would have any bearing on the functionality of flex fuel. If you are fuel limited, you are fuel limited, regardless of if it's an OTS tune or a custom tune, unless tuners now have magic to not need better LPFPs and supplemental HPFPs.