How would you account for a secondary fuel injection control mechanism in the DME? It will be neat to see if/how this works with those running PI, but I'd be a bit apprehensive unless they have some way to modify the PI controller as well.
Since we are talking about PI or a double barrel HPFP the only thing we are concerned with is the interpolation on fuel. All the other interpolation values that flex fuel brings to the table are generally not concerning to us in this conversation (generally). As a general rule of thumb gasoline has 30% more energy density than ethanol. So your fueling scalers are almost always in the neighborhood of 1.0 for gas and 1.29-1.31 for ethanol. If you are switching from gas to ethanol to get you in the right ballpark you add 30% fuel.
PI and Double Barrels are set up with a static map. You could certainly have a gasoline map, and add 30% to that and get a decent ethanol map. But you don't need to. You can split the difference and sit your PI/Double Barrel at 15% more fuel than gas.
What does that mean to the DME tune? Means for your gasoline portion you will need to retune to reduce fueling. For your ethanol portion you'll need to retune to increase fueling. Then you let your DME interpolate the fueling values in your new tune where your AIC is essentially splitting the difference and never changing...but the DME is changing everything on its end.
Conceptually not difficult....but in practice it might take tuners a bit of time to get themselves some base maps setup for this type of scenario. Probably add another layer of charges/fees to account for this. But technically it's no problem.